SPHINGOLIPIDOSES

      DISORDER           

   ENZYME DEFECTS

STORAGE       PRODUCT

TISSUE DIAGNOSIS

GAUCHER                                                                                  

GLUCOCEREBROSIDASE

GLUCOSYLCERAMIDE 

WBC,

SPLEEN

LIVER, MARROW,

NEURONS

GM2 GANGLIOSIDOSES

TAY-SACHS

SANDHOFF     

 

 

AB VARIANT                                         

                                                      

 

HEXOSAMINIDASE  A              

HEXOSAMINIDASE  B (AND A)

 

GM2 ACTIVATOR PROTEIN

 

GM2 GANGLIOSIDE       

GM2 GANGLIOSIDE   &  OTHER GLYCOCONJUGATES                    

 

GM2 GANGLIOSIDE       

 

WBC, NEURONS

WBC, NEURONS,LIVER, MARROW

 

WBC, NEURONS

NIEMANN-PICK                           

SPHINGOMYELINASES                                 

SPHINGOMYELIN & CHOLESTEROL

NEURONS, GLIA,SPLEEN, LIVER,MUSCLE, GI

METACHROMATIC 

LEUKODYSTROPHY           

ARYL SULFATASE  A

SULFATIDES

NEURONS, GLIA KIDNEY

 GM1 GANGLIOSIDOSIS

  b-GALACTOSIDASE                         

GM1 GANGLIOSIDE & OTHER GLYCONES

WBC, NEURONS,KIDNEY, LIVER,MARROW, GI

  KRABBE                                  

GALACTOCEREBROSIDASE

GALACTOSYLCERAMIDE                             & PSYCHOSINE

NEURONS, GLIA

  FABRY                                  

  a-GALACTOSIDASE   

CERAMIDE TRIHEXOSIDES

SKIN, SPLEENMARROW, LIVER, MUSCLE, KIDNEY

  FARBER                           

CERAMIDASE

CERAMIDE      

NEURONS, LIVER, GI,LYMPH NODES

 BATTEN                                                                                     

                                                           

                                                                                                                                                                                                                       

UNKNOWN      

LIPOFUSCIN-LIKE SUBSTANCES

NEURONS, LIVER, MUSCLE, GI, WBC, PANCREAS, SWEAT GLANDS,KIDNEY           

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