HISTORY: Endometrial tissue from 32 year-old woman with vaginal bleeding and history of an abortion 2 months ago. Eight microscopic images from H&E preparations are presented.

Differential Diagnosis:
1. Hydatidiform Mole
2. Chorioadenoma Destruens (Invasive Mole)
3. Chorio Carcinoma
4. Any other (please specify)

Please reply to  mkbaruah@pathoindia.com before September 3rd 2000.

  
A - 40x        B - 40x

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C - 40x        D - 40x

  
E - 100x        F - 100x

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G - 200x        H - 200x

This is a case of HYDATIDIFORM MOLE (Complete) with marked Trophoblastic proliferation. It is not Chorioadenoma Destruens (Invasive Mole) because no myometrial or vascular invasion is seen; this is essentially an endometrial curretage. It is not Choriocarcinoma because the presence of villi excludes it.

Dr. Baruah's report was Hydatidiform Mole with marked trophoblastic proliferation, with a comment suggesting to explore (i.e. by ultraSound) for myometrial invasion to exclude invasive mole.

Please, send further comments and/or discussion of this case to Dr. M K Baruah