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Journal Reviews
by Dr. Neha Dahiya, DCP, DNB (Path) USA Hello!
This is the first review I have put
up. I have tried to make it as short as possible and readable, and have tried
to avoid mistakes in content and transcription. But still to err is but human...... I hope you can overlook it........ but please feel free to forward your opinion / criticism on the write up which follows
American
Journal of Clinical Pathology
Vol.
117, Issue 1, Jan 2002
This is
one of my favorite journals as it encompasses articles related to all
subspecialties of our chosen area of expertise Pathology. So I
decided to start the Journal club reviews with articles from this journal. There were a couple of articles on Thyroid pathology and since we all get quite a few of those in our practice I am summarizing a couple of them.
1. In the editorial /
original article section there is an article by Andrew A. Renshaw MD and
Edwin W Gould MD from dept of Pathology, Baptist Hospital of Miami, Florida. Title: Why there is the Tendency to overdiagnose
the Follicular variant of Papillary Thyroid carcinoma. In this article the authors have brought up the issue of
overdiagnosis. It attributes private practitioners in pathology with a tendency
to overdiagnose. This is exemplified by an anecdote told by Juan Rosai.
He was asked by a private pathologist, to give consultation on an atypical
melanocytic lesion. Dr Rosai after much deliberation labeled it as Benign.
The friend thanked him for his opinion but opted to give the diagnosis of Malignant
Melanoma. His rationale for this was:
If
the diagnosis is malignant melanoma and patient does not come back, everyone is
happy that the pt. has been cured.
If
the diagnosis is given as benign lesion and the pt. comes back with recurrence
the pathologist ends up making rounds of Court. The authors say that defensive pathology has become
ingrained in the psyche of most private pathologists. It used a lot in
diagnosing the following lesion. The lesion under discussion is the Purely follicular variant of papillary thyroid
carcinoma. (PTC). Lindsay
first described this in 1960. And as we all know it must have characteristic
nuclear features of a papillary carcinoma in addition to predominant follicular
pattern to be so diagnosed. Despite
being recognized well as an entity, this variant is not well
characterized.It is often well circumscribed and encapsulated. The question raised is ....... What is the minimum
histologic definition of follicular variant of PTC??? Do occasional grooved nuclei, or those with pale chromatin
qualification enough to give the
diagnosis. Should these be uniformly present or not? Are they the pseudo
clear nuclei or true ground glass nuclei? A couple of studies have been done which summarize that at
least 25% of these patients had regional lymph node mets / distant mets. Thus
these neoplasms though indolent in behavior can cause distant metastasis. When faced with a solitary nodule the pathologists have to
decide whether this follicular nodule is a neoplasm or a dominant nodule of
goiter. There has been a lowering of threshold of follicular
variant of PTC as observed by the authors. The reasons given are.
Rare
aggressive clinical behavior of the neoplasm
Lack
of strict diagnostic criteria
Surgeons
increased willingness to do sub total thyroidectomies
Use
of radioactive iodine by endocrinologists after surgery for minimally invasive
follicular variant of PTC
Majority
cytologies with minimal findings are reported as atypical cannot rule out
papillary carcinoma...... hence leading to surgery The limitations of diagnostic criteria on cytology and
histopathology lead to overdiagnosis along with the combination of aggressive
surgeons/ endocrinologists. So , the question arises as to what should be done? The authors solutions
(though they claim its not easy to come by solutions): 1)
To
conduct a study to review inter observer variability and reach some conclusion. 2)
To
convene a consensus conference to arrive at a reproducible minimal diagnostic
criteria 3)
OR
---- To use the terminology of well differentiated tumour of uncertain
malignant potential, for tumours, which are encapsulated and show some
nuclear features of a typical papillary carcinoma. The authors conclude that no consensus criteria is
available and only nuclear cytology is still used. And they say As long as we are forced to practice in a legally exposed climate, we will continue to use a very low threshold for the diagnosis, since we would much rather cure some patients with benign disease than see patients with malignant disease in court .
2. In the same journal John K. C. Chan has an article titled
Strict criteria should be applied in the diagnosis
of encapsulated follicular variant of papillary thyroid carcinoma. He states that
Follicular
adenoma is a benign lesion
Encapsulated
variant of PTC papillary or purely follicular variant have an excellent
prognosis Thus John KC Chan proposes it is justified to err on the
benign side when there are uncertainties in the diagnosis. He is not much bothered about legal hassles and does not
advocate overdiagnosis. According to his experience since no single morphologic
feature is pathognomic of PTC a constellation of features has to be looked
into. He has formulated the following criteria for diagnosis of
encapsulated follicular variant of PTC 1)
Oval
rather than round nuclei 2)
Crowded
nuclei, emphasizing loss of polarity 3)
Clear nuclei or those with pale chromatin and
not artifactually localized to centre of the nucleus. 4)
Presence
of Psammoma bodies. If one of these four is missing the following subsidiary
features have to be present for diagnosis. i)
Presence
of abortive papillae ii)
Predominantly elongated or irregularly shaped
follicles iii)
Dark
staining colloid iv)
Presence
of rare nuclear pseudoinclusions. v)
Multinucleated
histiocytes in lumens of follicles This author also agrees to the use of terminology like Well differentiated thyroid tumour of uncertain malignant
potential when capsular or vascular invasion is not present AND Well differentiated thyroid carcinoma, not otherwise specified when there is definite capsular or vascular invasion (to distinguish between PTC and follicular carcinoma)
3. Well if you PIs are not yet bored of thyroid and thyroid
and more thyroid......there is some more of it. TITLE: Follicular patterned lesion of the
thyroid The bane of
the pathologist Zubair W. Baloch, Virginia A. Li Volsi University of Pennsylvania Medical Centre, Philadelphia. I am not going to write much about this article, as it is
quite basic, highlighting cytologic and histologic criteria of follicular
patterned lesions of thyroid. Though I will mention a few interesting points mentioned
by the authors which they follow in their practice. Use of the term minimally invasive follicular carcinoma for
tumours that show capsular invasion only Use of grossly
encapsulated angioinvasive follicular carcinomas for tumours with
vascular invasion with or without capsular invasion Most studies recommend 10 tissue
blocks representing tumour capsule and thyroid parenchyma to rule out capsular
invasion Plus the authors also have referred to Hybrid tumours These show features
of both follicular and papillary cancer. These lesions grow as solitary
encapsulated tumours like follicular carcinoma and also show some nuclear
features suggesting papillary carcinoma. Majority of such tumours exhibit
vascular invasion. Further studies are required to classify them as an entity. It will be good for the postgraduates to read this article, that is, if they are interested enough. I know at least I used to collect such articles and make an attempt to go through them.
Finally we leave thyroid
aside and move to other topics. For our journal reviews as a postgraduate student I
used to try and review something from journals other than pathology. So I will
try and get something interesting from other avenues of science and medicine. The following information was mentioned to me by my
professor Dr. Karuna Rameshkumar - an excellent teacher a wonderful human being
with a very loving and compassionate heart. We all are aware of the Nobel Prize some may
secretly wish to achieve it one day, and maybe rightly so. Few of us know about the Ig Nobel Prize or the
IGNOBEl Prize???? It was first presented by the Journal of
Irreproducible Results in 1968 The Ignobel Laureates are honoured for their irreproducible achievements in science and
other areas of human endeavor. The winners have been consigned to the realms of
obscurity. More about this can be seen on ....
http://www.improb.com/ig/ig-pastwinners.html. - In 2001 IgNobel prize in medicine was awarded toPeter Barss of Mc. Gill Univ. for his study on "Injuries Due to Falling Coconuts" [Published in: The Journal of Trauma vol. 21, no. 11, 1984, pp. 990-1.] - Chittaranjan Andrade, MD & B. S. Hari, MBBS from
NIMHANS, Bangalore got the prize in Public Health This was awarded for their unique work on the nose picking behaviour in adolescents.It has been published in "A Preliminary Survey of Rhinotillexomania in an Adolescent Sample" Journal of Clinical Psychiatry, vol. 62, no. 6, June 2001, pp. 426-31. Rhinotillexomania is a recently coined term for
compulsive nose picking.
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